Conjugate Vaccines from Bacterial Antigens by Squaric Acid Chemistry: A Closer Look

Bacterial polysaccharide±protein conjugate vaccines*

The age-related and T-cell independent properties of polysaccharides limit their use as vaccines. These limitations are overcome by covalently binding polysaccharides to proteins to form conjugates. Widespread use of Haemophilus in ̄uenzae type b (Hib) conjugates has virtually eliminated systemic infection caused by this pathogen, notably meningitis, in individuals of all ages. The principles de...

Auctions : A Closer Look

A ClOser lOOk

In recent years, systems of care principles have been increasingly adopted because of their potential to support efforts to improve child welfare and other human service systems in ways that lead to increased safety, permanency, and well-being for children, adolescents, and their families. However, while the systems of care approach has become more widespread, a clear understanding of what defi...

Red - Take a Closer Look

Color research has shown that red is associated with avoidance of threat (e.g., failure) or approach of reward (e.g., mating) depending on the context in which it is perceived. In the present study we explored one central cognitive process that might be involved in the context dependency of red associations. According to our theory, red is supposed to highlight the relevance (importance) of a g...

A Closer Look at Preduction

In a recent paper Jun Arima formalises the idea of preduc-tion { a non-monotonic schema providing a common basis for inductive and analogical reasoning. We examine some of the implications of this schema, as well as its connections with prototypes and conceptual spaces. A generalised version of his schema is motivated and developed to address diiculties with asymmetry and disjuncts.